I refer to the notion of mimicking successful public health inoculation policies (think smallpox eradication) and ensuring that every computer bought in any shop (or online) is protected with a powerful vaccine: modern antivirus software. That way, users would be protected at source from everything from ID-theft-fuelling keyloggers to the bot infections behind megadollar phishing and DDoS attacks. And when ISPs sense a PC is spitting out phishing spam or service-denial packets, they could cut the internet connection until the machine is vaccinated.
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